半岛bd体育手机客户端 说明
一般描述
KCTD3 (potassium channel tetramerization domain containing 3) belongs to the KCTD protein family, which is highly expressed in brain, and some other tissues. In certain regions of brain, such as hypothalamus, it co-localizes with HCN3 (hyperpolarization-activated cyclic nucleotide-gated channel 3). It interacts with HCN3 through half of its C-terminal. Its N-terminal contains bric-à-brac, tramtrak, and broad complex (BTB) motif, which is characteristic of KCTD family. It also contains five copies of WD repeats. This gene is localized to human chromosome 1q41.
免疫原
BTB/POZ domain-containing protein KCTD3 recombinant protein epitope signature tag (PrEST)
应用
Anti-KCTD3 antibody is suitable for immunoprecipitation. Anti-KCTD3 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
生化/生理作用
KCTD3 (potassium channel tetramerization domain containing 3) leads to a significant increase in the expression levels of HCN3 (hyperpolarization-activated cyclic nucleotide-gated channel 3) protein in the brain. Therefore, it is implicated in the correct transport of HCN3 complexes to plasma membrane. In a single case of autistic boy, this gene was found to be inactivated paternally.
特点和优势
Prestige Antibodies?are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies?to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
联系
Corresponding Antigen APREST72513.
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
人类蛋白质图谱编号 | HPA015142 Human Protein Atlas characterization data |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
半岛bd体育手机客户端 线 | Prestige Antibodies?Powered by Atlas Antibodies |
形式 | buffered aqueous glycerol solution |
species reactivity | human |
包装 | antibody small pack of 25 μL |
technique(s) | immunofluorescence: 0.25-2 μg/mL immunohistochemistry: 1:50-1:200 |
免疫原序列 | ITPLVRRLLLCEELERSSCGSVLFHGYLPPPGIPSRKINNTVRSADSRNGLNSTEGEARGNGTQPVLSGTGEETVRLGFPVDPRKVLIVAGHHNWIVAAYAHFAVCYRIKESSGWQQVFTSP |
UniProt登记号 | Q9Y597 |
运输 | wet ice |
储存温度 | ?20℃ |
Gene Information | human ... KCTD3(51133) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich