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Anti-KCNMB4 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1407360
规格纯度
purified immunoglobulin, buffered aqueous solution
价格
5045.46 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-KCNMB4 antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Potassium calcium activated channel subfamily M regulatory β subunit 4 (KCNMB4) is mapped to human chromosome 12q14.1-15. The encoded protein is a member of the potassium channel β subunit family. KCNMB4 contains two transmembrane segments (TM1 and TM2), intracellular N and C terminal and a large extracellular loop. It is mainly expressed in the brain, neuronal tissue, kidney and bladder smooth muscle.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. (provided by RefSeq)

免疫原

KCNMB4 (NP_055320.4, 1 a.a. ~ 210 a.a) full-length human protein.

Sequence
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS

生化/生理作用

Potassium calcium activated channel subfamily M regulatory α subunit 4 (KCNMB4) plays a vital role in increasing Ca2+sensitivity. It reduces the voltage dependence of the conductance-voltage relationship as well as the slope of the gating charge-voltage curve.

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~23.9 kDa
species reactivity human
technique(s) western blot: 1 μg/mL
NCBI登记号 NM_014505
UniProt登记号 Q86W47
运输 dry ice
储存温度 ?20℃
Gene Information human ... KCNMB4(27345)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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