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位置: 首页> 品牌> Sigma-Aldrich> Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1
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Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1

品牌
Sigma-Aldrich
货号
MABC552
规格纯度
clone 11C7.1, from mouse
价格
5688.25 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1
Kallikrein-1, Kidney/pancreas/salivary gland kallikrein, Tissue kallikrein, Kallikrein-1/KLK1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Kallikrein-1 (EC:3.4.21.35; UniProt P06870; also known as Glandular kallikrein 1, hK1, Kallikrein serine protease 1, Kidney/pancreas/salivary gland kallikrein, Renal/pancreas/salivary kallikrein 1, Tissue kallikrein) is encoded by the KLK1 (also known as KLKR) gene (Gene ID 3816) in human. Kallikrein-1 is a member of the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used clinically as biomarkers for cancer. Kallikrein-1 is initially produced as a preproprotein with a signal (aa 1-18) and a propeptide (aa 19-24), cleavage of which releases the mature protein (aa 25-262). Kallikrein-1 is the major kallikrein expressed in the kidney, where it generates kinins (e.g. lysyl-bradykinin and bradykinin) and plays role in kidney function and blood pressure regulation through vasodilatory and natriuretic effects. Decreased kidney Kallikrein-1 level is reported in experimental settings of hypertension, diabetic nephropathy, high salt- and aminoglycoside-induced kidney injury.

免疫原

GST-tagged recombinant protein corresponding to the C-terminal half of human Kallikrein-1/KLK1.

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-1/KLK1 in human pancreas and human colon tissue.
This Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Kallikrein-1/KLK1.

质量

Evaluated by Western Blotting in human salivary gland tissue lysate.

Western Blotting Analysis: 0.2 ?g/mL of this antibody detected Kallikrein-1/KLK1 in 10 ?g of human salivary gland tissue lysate.

目标描述

~30 kDa observed. 28.9 kDa/isoform 1 and 23.8 kDa/isoform 2 calculated.

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified antibody
antibody product type primary antibodies
克隆 11C7.1, monoclonal
species reactivity human
technique(s) immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型 IgG2bκ
NCBI登记号 NP_002248
UniProt登记号 P06870
运输 dry ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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