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ANTI-ISL1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1412040
规格纯度
clone 8A3, purified immunoglobulin, buffered aqueous solution
价格
4618.16 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
ANTI-ISL1 antibody produced in mouse
ISL1
Isl-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Insulin gene enhancer binding protein-1 (ISL-1) gene spanning 220kb of genomic DNA, is mapped to human chromosome 5q11.1. The gene codes for a member of LIM zinc-binding/homeobox-domain transcription factor and is predominantly expressed in hindbrain, forebrain, ventral neural tube, dorsal root ganglia (DRG) and trigeminal ganglia.

免疫原

ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
YCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEP

生化/生理作用

Insulin gene enhancer binding protein-1 (ISL-1) is a transcription factor which plays a vital role in the development of the heart, motor neurons and pancreas. It also stimulates adult pancreatic ?-cells proliferation. ISL1 might also be involved in the regulation of insulin expression. Elevated expression of the gene has been observed in patients with gastric cancer. Thus, the protein can be used as a potential biomarker and therapeutic target for gastric cancer. Mutation in the gene is associated with the increased risk of susceptibility to human congenital heart disease (CHD).

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 8A3, monoclonal
形式 buffered aqueous solution
分子量 antigen 36.41 kDa
species reactivity human
technique(s) indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
同位素/亚型 IgG2aκ
NCBI登记号 NM_002202
UniProt登记号 P61371
运输 dry ice
储存温度 ?20℃
Gene Information human ... ISL1(3670)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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