Anti-Integrin beta1 Antibody, clone HM beta 1.1

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一般描述

Integrin beta 1is also known as CD29. It is a transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits, forming the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions such as hemostasis, embryonic development, wound repair, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion.

特异性

Other species have not been tested.

免疫原

Epitope: Full length
Purified mouse VLA-4 antigen

应用

Research Category
Cell Structure
Research Sub Category
Integrins
Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.

质量

Routinely evaluated by immunocytochemistry on mouse NIH3T3, A431 cells.

目标描述

130 kDa

外形

Purified in PBS with 0.05% NaN3.
Format: Purified
Protein G Purified

储存及稳定性

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

分析说明

Control
NIH3T3, A431

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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