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位置: 首页> 品牌> Sigma-Aldrich> Anti-Integrin β1 Antibody, clone 12G10

Anti-Integrin β1 Antibody, clone 12G10

品牌
Sigma-Aldrich
货号
MAB2247
规格纯度
clone 12G10, Chemicon?, from mouse
价格
6190.47 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Integrin β1 Antibody, clone 12G10
Integrin beta-1, CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Integrin beta-1 (UniProt P05556; also known as CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12, VLA-BETA, VLAB) gene (Gene ID 3688) in human. Integrin beta-1 is a 130 kDa transmembrane glycoprotein that interact with various integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptor complexes that bind to specific extracellular matrix proteins. Integrin receptors regulate a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor growth and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to the activation of signal transduction pathways and regulation of gene expression.

特异性

MAB2247 recognizes the human beta1 integrin. This antibody has been shown to recognize a ligand-induced binding site, with antibody binding increasing in the presence of a fibronectin ligand. This antibody also enhances alpha 5 - beta 1 fibronectin interactions. MAB2247 does not cross-react with mouse or rat samples.

免疫原

Purified human beta1 integrin preparation from HT1080 fibrosarcoma cell extract.

应用

Research Category
Cell Structure
Anti-Integrin β1 Antibody, clone 12G10 detects level of Integrin β1 & has been published & validated for use in ELISA, FC, IP, FUNC, CULT & WB.
Research Sub Category
Integrins
Flow cytometry: 1:25-1:50

ELISA : 10 μg/mL

Western Blot: known to react with human beta 1 integrin subunit under non-reduced conditions only {Mould, 1995}.

Stimulatory to alpha5beta1 interaction with fibronectin {Mould, 1995}.

Optimal working dilutions must be determined by end user.

目标描述

88 kDa

外形

Purified immunoglobulin. Liquid in phosphate buffer saline, with 0.1% sodium azide.
Format: Purified
Protein A purified

储存及稳定性

Maintain refrigerated at 2–8°C in undiluted aliquots for up one month. For long term storage maintain at -20°C for up to 12 months.

分析说明

Control
Tonsil, human skin tissue

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 12G10, monoclonal
species reactivity human
manufacturer/tradename Chemicon?
technique(s) ELISA: suitable
cell culture | mammalian: suitable
flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NM_002211
UniProt登记号 P05556
运输 dry ice
Gene Information human ... ITGB1(3688)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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