Anti-InsP3R Antibody, Type 1

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一般描述

The inositol (1,4,5)-trisphosphate receptor (InsP3R) regulates calcium release from storage within cells and plays an important role in neuronal function. InsP3R has been linked to Huntington’s disease. InsP3R has also been linked to the association between cAMP and Ca2+ signaling in regions of the brain, including the neostriatum.

特异性

This antibody recognizes InsP3R at the cytoplasmic domain.

免疫原

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of rat InsP3R.

应用

This Anti-InsP3R Antibody, Type 1 is validated for use in WB, IP, IH(P) for the detection of InsP3R.
Immunohistochemistry Analysis: 1:1500 dilution from a previous lot detected InsP3R in purkinje cells at the junction of the granular and molecular layers of normal rat cerebellum tissue.

Immunoprecipitation Analysis: 10 ?g of Anti-InsP3R, Type 1 immunoprecipitated InsP3R, Type 1 from rat brain microsomal prep RIPA lysate.

质量

Evaluated by Western Blot in rat brain microsomal tissue lysate.

Western Blot Analysis: 0.1 ?g/mL of this antibody detected InsP3R on 10 ?g of rat brain microsomal tissue lysate.

目标描述

~300 kDa observed. UniProtKB/Swiss-Prot P29994 (ITPR1_RAT) entry describes 8 isoforms produced by alternative splicing: Isoform 1 at 313.264 kDa, Isoform 2 at 311.498 kDa, Isoform 3 at 313.136 kDa, Isoform 4 at 311.370 kDa, Isoform 5 at 311.210 kDa, Isoform 6 at 309.444 kDa, Isoform 7 at 308.674 kDa, and Isoform 8 at 306.909 kDa

外形

Affinity purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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