半岛bd体育手机客户端 说明
一般描述
IL1RL1, or Interleukin-1 receptor-like 1 protein, which is also known as Lymphocyte antigen 84, Protein ST2, or Protein T1, and encoded by the gene IL1rL1/Ly84/St2/Ste2 is the receptor for IL-33 and its activation recruits MYD88, IRAK1, IRAK4 and TRAF6 transcription factors and promotes the activation of ERK1/MAPK14 and MAPK8. IL1RL1 also is involved in T-helper Cell activation and function. IL1RL1 is localized to the plasma membrane. IL1RL1 is expressed in hematopoietic tissues, macrophages, epithelial and fibroblast cells lines as well as important tissues such as heart and lung. IL1RL1 is a member of the Toll-like receptor superfamily and interestingly plays an important role not in inflammation but in cardiac protection. When IL-33 binds it elicits a cardioprotective signaling response in the tissue and thus helps protect the heart tissue during times of ischemia for instance. Defects in IL1RL1 have been linked to atopic dermatitis and asthma.
免疫原
Mouse ST-2/IL1RL1.
应用
Anti-IL1RL1 antibody, clone RMST-2, Azide Free is an antibody against IL1RL1 for use in flow cytometry & activity assay.
Activity Assay Analysis: A representative lot from an independent laboratory induces IL-6 production in BMCC cells (Prof. Hisaya Akiba, Jutendo University).
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology
质量
Evalauted by Flow Cytometry in ST2/L5178Y and L5178Y parent cells.
Flow Cytometry Analysis: 1 ?g of this antibody detected IL1RL1 in 1X10E6 ST2/L5178Y cells.
目标描述
64 kDa calculated
外形
Format: Purified
Purified rat monoclonal IgG2aκ in buffer containing PBS without preservatives.
Protein G Purified
储存及稳定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | rat |
| 抗体形式 | purified antibody |
| 克隆 | RMST2-2, monoclonal |
| species reactivity | mouse |
| technique(s) | activity assay: suitable flow cytometry: suitable |
| 同位素/亚型 | IgG2aκ |
| NCBI登记号 | NP_001020773 |
| UniProt登记号 | P14719 |
| 运输 | wet ice |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
