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位置: 首页> 品牌> Sigma-Aldrich> Anti-IL-32 Antibody

Anti-IL-32 Antibody

品牌
Sigma-Aldrich
货号
ABS433
规格纯度
from rabbit, purified by affinity chromatography
价格
5688.25 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-IL-32 Antibody
Interleukin-32, IL-32, Natural killer cells protein 4, Tumor necrosis factor alpha-inducing factor, NK4, TAIF
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Interleukin-32 (IL-32), also known as Natural killer cells protein 4 (NK4) and Tumor necrosis factor alpha-inducing factor (TAIF), may play a role in innate and adaptive immune responses. IL-32 induces various cytokines such as TNFA/TNF-alpha, MIP-2 and IL-8, and activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. IL-32 has been shown to be induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFN gamma, and it has been suggested to play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis. IL-32 is different from other known cytokine families because it does not share sequence homology with them and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. IL-32 is selectively expressed in lymphocytes and expression is more prominent in immune cells than in non-immune cells. The expression of IL-32 increased after activation of T-cells by mitogens and after activation of NK cells by IL2/interleukin-2.

特异性

This antibody recognizes two isoforms at ~14 kDa and ~22 kDa at the C-terminus of IL-32.

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of human IL-32.
Epitope: C-terminus

应用

Immunohistochemistry Analysis: 10 ?g/mL from a representative lot detected IL-32 in human spleen tissue.

Immunofluorescence Analysis: 20 ?g/mL from a representative lot detected IL-32 in human spleen cells.
Research Category
Signaling
Anti-IL-32 Antibody is a highly specific rabbit polyclonal antibody, that targets IL-32 & has been tested in western blotting, IHC & Immunofluorescence.
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blot in human spleen tissue lysate.

Western Blot Analysis: 5 ?g/mL of this antibody detected IL-32 in 15 ?g of human spleen tissue lysate.

目标描述

~14 kDa and ~22 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 5 isoforms between ~15 kDa and ~27 kDa

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human spleen tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt登记号 P24001
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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