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Anti-Human IgG1 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200786
规格纯度
clone 8C/6-39, purified from hybridoma cell culture
价格
6564.11 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Human IgG1 antibody, Mouse monoclonal
Anti-Human immunoglobulin G1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Human IgGs consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5 and 4% of the total IgG, respectively. Each subclass has different biological and physiochemical properties. The IgG subclass may be preferentially produced in response to different antigens and pathological conditions. For instance, anti-polysaccharide responses are mainly of the IgG2 subclass while protein antigens give rise to IgG1 and IgG3 antibodies. Human IgG1 is the predominant subclass of in vivo and in vitro produced anti-tetanus toxoid antibodies. IgG1 and IgG3 are the only subclasses capable of adherence to mononuclear phagocytes and are recognized readily by the Fc receptors on various reticulo-endothelial cells while IgG2 and IgG4 are far less efficient. The amount of the different IgG subclasses present in the bloodstream varies with age. For example, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels raise more slowly, reaching adult levels at about 10 years of age. Serum IgG subclass deficiencies have been recorded for different patient groups. For example, a disproportionate elevation of IgG1 has been found in the cerebral spinal fluid of patients with multiple sclerosis. Examination of the distribution pattern of IgG subclasses in different types of diseases may provide insight into the immunological processes involved and thus may assist in the diagnosis of various disorders.

免疫原

The Fc fragment of a human IgG1 myeloma protein.

应用

Indirect ELISA: a working concentration of 3-6 μg/mL is recommended using 10 μg/mL Human IgG1 myeloma protein for coating.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15mM sodium azide.

其他说明

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

基本信息

NACRES NA.46

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 8C/6-39, monoclonal
形式 buffered aqueous solution
species reactivity human
浓度 ~1 mg/mL
technique(s) indirect ELISA: 3-6 μg/mL using Human IgG1 myeloma protein for coating.
同位素/亚型 IgG2a
运输 dry ice
储存温度 ?20℃

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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