Anti-Hu GBP-1/GBP-1 Antibody, clone 6C5.1

半岛bd体育手机客户端 说明

一般描述

mgbp-2/hGBP-1, or also known as Interferon-induced guanylate-binding protein 1, GTP-binding protein 1 (GBP-1/HuGBP-1), or Guanine nucleotide-binding protein 1, and encoded by the gene GBP1, is another enzyme important in innate defense. Among its functions, this enzyme hydrolyzes GTP to GMP and appears to promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, thus providing broad host protection against different pathogen classes. mgbp-2/hGBP-1 is localized to the cytoplasm but is also secreted in endothelial cells and localizes to the cytoplasmic side of the Golgi apparatus in expressing most cells. Interestingly, mgbp-2/hGBP-1is secreted by the endothelial cells in the CNS upon bacterial challenge even when not induced by gamma interferon. The enzyme is also induced by TNF-alpha and IL-1beta expression by immune cells and is considered a proinflammatory response factor.

免疫原

GST-tagged recombinant protein corresponding to hu GBP-1/GBP-1.

应用

Research Category
Cell Structure
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected hu GBP-1/GBP-1 in human spleen tissues and rat brain tissue.
This Anti-Hu GBP-1/GBP-1 Antibody, clone 6C5.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Hu GBP-1/GBP-1.
Research Sub Category
ECM Proteins

质量

Evaluated by Western Blotting in human spleen tissue lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected hu GBP-1/GBP-1 in 400 ?g of human spleen tissue lysate.

目标描述

~68 kDa observed

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified antibody
antibody product type	primary antibodies
克隆	6C5.1, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_002044
UniProt登记号	P32455
运输	wet ice
Gene Information	human ... GBP1(2633)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable