Anti-Homeodomain-only Protein Antibody, clone 15C1.1

半岛bd体育手机客户端 说明

一般描述

Homeodomain-only protein (UniProt Q9BPY8; also known as Lung cancer-associated Y protein, Not expressed in choriocarcinoma clone 1, Not expressed in choriocarcinoma protein 1, Odd homeobox 1 protein, Odd homeobox protein 1) is encoded by the HOPX (also known as CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO) gene (Gene ID 84525) in human. Human and mouse HOPX proteins share 92% identity, they contain homeobox-like domain but lack sequence motif required for DNA binding. HOPX is highly expressed in the developing heart, where its expression is dependent on the cardiac-restricted homeobox protein, Nkx2.5. HOPX physically interacts with serum responsive factor (SRF) and inhibits SRF-dependent transcription by inhibiting SRF binding to DNA and by recruiting histone deacetylase (HDAC) activity. HOPX is reported to play a critical role in the differentiation of various cells such as myoblasts, trophoblasts, keratinocytes, T cells, and lung alveolar cells. HOPX was initially reported as a differentiation marker and is expressed in various normal tissues, and HOPX expression is markedly suppressed in a subset of cancers.

特异性

Expected to react with spliced isoforms 1, 3, and 4. Reactivity toward isoform 2 has not been determined.

免疫原

GST-tagged recombinant protein corresponding to human Homeodomain-only Protein.

应用

Research Sub Category
Nuclear Receptors
This Anti-Homeodomain-only Protein Antibody, clone 15C1.1 is validated for use in Western Blotting for the detection of Homeodomain-only Protein.
Research Category
Epigenetics & Nuclear Function

质量

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected Homeodomain-only Protein in 10 ?g of mouse lung tissue lysate.

目标描述

~10 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss

32160702

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	15C1.1, monoclonal
species reactivity	mouse
species reactivity (predicted by homology)	human (based on 100% sequence homology)
technique(s)	western blot: suitable
同位素/亚型	IgG2bκ
NCBI登记号	NP_001138931
UniProt登记号	Q9BPY8
运输	wet ice
Gene Information	human ... HOPX(84525)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable