ANTI-HIF1ALPHA(C-TERMINAL) antibody produced in rabbit

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一般描述

Hypoxia-inducible factor-1 (HIF1) is a transcription factor expressed in mammalian cells when cultured under reduced oxygen tension. HIF1 is a heterodimer composed of an α subunit and a β subunit. The β subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. HIF-1α contains two transactivation domains. The gene encoding it is localized on human chromosome 14q23.2.

生化/生理作用

Hypoxia-inducible factor-1 (HIF1) plays an essential role in cellular and systemic homeostatic responses to hypoxia. During hypoxia, the two subunits of this factor undergo post-translational modifications, which in turn promote transactivation. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. HIF-1α is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF).

外形

Supplied in PBS with 0.09% (W/V) sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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