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位置: 首页> 品牌> Sigma-Aldrich> Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1

Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1

品牌
Sigma-Aldrich
货号
MABC582
规格纯度
clone 11D12.1, from mouse
价格
5688.25 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1
Baculoviral IAP repeat-containing protein 3, Apoptosis inhibitor 2, API2, C-IAP2, IAP homolog C, Inhibitor of apoptosis protein 1, IAP-1, hIAP-1, hIAP1, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1, hIAP-1/BIRC3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Baculoviral IAP repeat-containing protein 3 (UniProt Q13489; also known as API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing 3, c-IAP2, hIAP-1, hIAP1, IAP homolog C, IAP-1, Inhibitor of apoptosis protein 1, Mammalian IAP homolog C, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1) is encoded by the BIRC3 (also known as API2, AIP1, IAP1, HAIP1, HIAP1, MALT2, MIHC, RNF49) gene (Gene ID 330) in human. hIAP-1 (c-IAP2) belongs to the inhibitor of apoptosis (IAP) family of proteins characterized by the presence of at least one baculoviral IAP repeat (BIR) domain. hIAP-1 (c-IAP2 contains three BIR (BIR1/2/3) domains, followed by an UBA (ubiquitin-associated), a CARD (caspase activation and recruitment domain), and a RING (really interesting new gene) domain. The BIR domains mediate hIAP-1 interaction with various binding partners, such as caspases, other IAP family members, and receptor-associated complexes. The RING domain and its associated E3 ligase mediates not only the ubiqutination of substrate proteins, such as caspase-3, caspase-7, SMAC/DIABLO, but also self-ubiquitylation. The UBA domain enables hIAP-1 to engage protein complexes containing poly-ubiquitylated protein(s).

免疫原

GST-tagged recombinant protein corresponding to the BIR 1/2 of human hIAP-1/BIRC3.

应用

Western Blotting Analysis: 1.0 ?g/mL from a representative lot detected hIAP-1/BIRC3 in 10 ?g of TF-1, Jurkat, and Molt-4 cell lysate.
Research Sub Category
Apoptosis - Additional
Detect BIRC3 using this mouse monoclonal Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1, Cat. No. MABC582, validated for use in Western Blotting.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected hIAP-1/BIRC3 in 10 ?g of K562 cell lysate.

目标描述

~60 kDa observed

外形

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 11D12.1, monoclonal
species reactivity human
technique(s) western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_001156
UniProt登记号 Q13489
运输 dry ice
Gene Information human ... BIRC3(330)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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