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Anti-Hec1 Antibody

品牌
Sigma-Aldrich
货号
ABE1302
规格纯度
from rabbit, purified by affinity chromatography
价格
5352.52 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-Hec1 Antibody
Kinetochore protein NDC80 homolog, Highly expressed in cancer protein, Kinetochore protein Hec1, HsHec1, Kinetochore-associated protein 2, Retinoblastoma-associated protein HEC, Hec1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The protein HEC1 (highly expressed in cancer 1) is an essential component of the vital NDC80 kinetochore-associated protein complex. The NDC80 complex is required for chromosome segregation and spindle checkpoint activity. HEC1 is essential for proper kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. HEC1 is expressed by all dividing cells and is particularly high in cancers. HEC1 localizes to kinetochores from late prophase to anaphase, specifically at the outer plate of the kinetochore. HEC1 is normally phosphorylated during its active phase at multiple sites and the phosphorylation appears to tune kinetochore-microtubule binding affinity during mitosis. Moreover, recent research using small molecule inhibitors to HEC1′s kinase, Nek2, demonstrate that phosphorylation is required for proper HEC1 function.

免疫原

Epitope: Nuclear localization region
KLH-conjugated linear peptide corresponding to the Nuclear localization region of human Hec1.

应用

Research Sub Category
Nuclear Receptors
Anti-Hec1 Antibody is an antibody against Hec1 Antibody for use in Western Blotting, Immunocytochemistry.
Research Category
Epigenetics & Nuclear Function
Immunocytochemistry Analysis: 1.0 ?g/mL from a representative lot detected Hec1 in HeLa cells.

质量

Evaluated by Western Blotting in SK-OV-3 cell lysate.

Western Blotting Analysis: 0.1 ?g/mL of this antibody detected Hec1 in 10 ?g of SK-OV-3 cell lysate.

目标描述

~78 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
species reactivity (predicted by homology) rat (based on 100% sequence homology), mouse (based on 100% sequence homology)
technique(s) immunocytochemistry: suitable
western blot: suitable
NCBI登记号 NP_006092
UniProt登记号 O14777
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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