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位置: 首页> 品牌> Sigma-Aldrich> Anti-GUCY2C (981-995) antibody produced in rabbit

Anti-GUCY2C (981-995) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1100176
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-GUCY2C (981-995) antibody produced in rabbit
Anti-guanylate cyclase 2C (heat stable enterotoxin receptor)
Anti-GUC2C
Anti-STAR
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The guanylate cyclase 2C (GUCY2C) gene is mapped to human chromosome 12p12. The gene codes for a transmembrane receptor guanylate cyclase C (GC-C) and is expressed in intestine.

免疫原

synthetic peptide corresponding to amino acids 981-995 of human GUCY2C

应用

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

生化/生理作用

Guanylate cyclase 2C (GUCY2C) converts guanosine-5′-triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), upon binding of its ligand guanylin and uroguanylin, which are paracrine hormones. GUCY2C functions as a tumor suppressor and hinders intestinal tumorigenesis by inhibiting the protein kinase B/AKT signaling pathway. Transmembrane receptor guanylate cyclase C (GC-C) regulates the secretion of chloride. Alteration in the gene expression leads to congenital sodium diarrhoea (CSD).

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~123 kDa
species reactivity human
technique(s) western blot: 1:500-1:2,000
UniProt登记号 P25092
运输 dry ice
储存温度 ?20℃
Gene Information human ... GUCY2C(2984)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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