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Anti-GPR174 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4503376
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-GPR174 antibody produced in rabbit
Probable G-protein coupled receptor 174
FKSG79
GPR174
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

G protein-coupled receptor 174 (GPR174) is a 333 amino acid protein encoded by the gene with one exon mapped to human chromosome Xq21.1. GPR174 is a member of G protein–coupled receptor 1(GPCR1) / rhodopsin-like family. The encoded protein consists of seven α -helical transmembrane domains. The protein is predominantly expressed in immune related tissues, and it is expressed at low levels in thyroid.

免疫原

The antiserum was produced against synthesized peptide derived from human GPR174.

Immunogen Range:131-180

生化/生理作用

G protein-coupled receptor 174 (GPR174) plays a vital role in inducing signal transduction in immune cells. GPR174 upon lysophosphatidylserine (LysoPS) binding, enhances the production of intracellular cyclic adenosine monophosphate (cAMP) in a dose dependent manner. Mutation in GPR174 gene can be a risk factor for Graves′ disease (GD) and autoimmune addison′s disease (AAD). Upregulation of intracellular cAMP by GPR174 leads to the inhibition of immune cell proliferation. GPR174, as a LysoPS receptor, might play a crucial role in the central nervous system. Alteration in the expression of the gene results in vasovagal syncope (VVS). Overexpression of GPR174 is observed in subcutaneous metastases. Lysophosphatidylserine (LysoPS) secreted by the immune systemin vivo, acts as a ligand for GPR174.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 38 kDa
species reactivity human
浓度 ~1 mg/mL
technique(s) ELISA: 1:40000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号 Q9BXC1
运输 wet ice
储存温度 ?20℃
Gene Information human ... GP174(84636)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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