Anti-GPAT-1 Antibody

半岛bd体育手机客户端 说明

一般描述

Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT-1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT-1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT-1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT-1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets.

免疫原

KLH-conjugated synthetic peptide corresponding to the C-terminus of human GPAT-1.
Epitope: C-terminus

应用

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected GPAT-1 in rat brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPAT-1 in rat brain cells.




Anti-GPAT-1 Antibody is an antibody against GPAT-1 for use in western blotting, IHC & immunofluorescence.
Research Category
Signaling
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected GPAT-1 in rat brain tissue lysate.

目标描述

~82 kDa observed. Uncharacterized bands may be observed in some lysate(s).

联系

Replaces: MABS402

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	rat
technique(s)	immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable
UniProt登记号	Q9HCL2
运输	wet ice
Gene Information	human ... GPAM(57678)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable