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位置: 首页> 品牌> Sigma-Aldrich> Anti-Glypican-6 Antibody, clone 6A7.1

Anti-Glypican-6 Antibody, clone 6A7.1

品牌
Sigma-Aldrich
货号
MABN531
规格纯度
clone 6A7.1, from mouse
价格
5688.25 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-Glypican-6 Antibody, clone 6A7.1
Glypican-6, Secreted glypican-6
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The protein named Glypican-6 and encoded by the gene GPC6, is a cell surface membrane proteoglycan protein that contains heparan sulfate residues and appears to act as a cellular receptor for various growth factors, ECM proteins, and enzymes. Moreover, Glypican-6 when over expressed enhances the migration and invasion of many cancer cells through the direct activation of the WNT5A signaling pathway. Additionally, Glypican-6 serves a developmental function as it is highly expressed in fetal tissues and defects give rises to severe dysmorphism and congenital defects. Glypican-6 is widely expressed in critical fetal tissues from kidney to brain, and in the adult high expression is seen in ovary, kidney, intestines and liver, and abundant in many cancer cells. Defects in Glypican-6 are associated with Omodysplasia 1 a rare autosomal recessive skeletal dysplasia characterized by facial dysmorphism and severe congenital micromelia giving club-like appearance to hands and feet.

特异性

Should detect both pro and secreted for Glypican-6 by immunogen design

免疫原

GST-tagged recombinant protein corresponding to human Glypican-6.

应用

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Glypican-6 in human ovarian follicles and human oviduct tissue.
Research Category
Neuroscience
Detect Glypican using this mouse monoclonal antibody, Anti-Glypican-6 Antibody, clone 6A7.1 validated for use in western blotting & IHC.
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in mouse liver tissue lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected Glypican-6 in 10 ?g of mouse liver tissue lysate.

目标描述

~62 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified antibody
antibody product type primary antibodies
克隆 6A7.1, monoclonal
species reactivity mouse, human
technique(s) immunohistochemistry: suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_005699
UniProt登记号 Q9Y625
运输 wet ice
Gene Information human ... GPC6(10082)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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