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位置: 首页> 品牌> Sigma-Aldrich> Anti-GBP5 Antibody

Anti-GBP5 Antibody

品牌
Sigma-Aldrich
货号
ABS381
规格纯度
from rabbit, purified by affinity chromatography
价格
5016.79 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-GBP5 Antibody
Guanylate-binding protein 5, GBP-TA antigen, GTP-binding protein 5, GBP-5, Guanine nucleotide-binding protein 5
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

GBP5, also known as GBP-TA antigen, or GTP-binding protein 5, or Guanine nucleotide-binding protein 5 or GBP-5, and encoded by the gene GBP5, is a protein that plays a role in the inflammatory response to pathogens and may also play a role in apoptosis. GBP5 stimulates cryopryrin (NLRP3 protein) assembly of the intracellular inflammasome, a multiprotein oligomer consisting of caspase 1, PYCARD, NALP and sometimes caspase 5. Inflammasomes act as sensory complexes that alert the immune system to the presence of infection or tissue damage. Nucleosomes and GBP5 are expressed in myeloid cells and are a component of the innate immune system; GBP5 acts as key rheostat for activation and assembly of the inflammasomes. Additionally, GBP5 is a GTPase that homodimerizes upon GTP-binding; dimerization is required for the second hydrolysis step from GDP to GMP. GBP5 is localized to the cytoplasm and intracellular membranes via its lipid-anchor sequences.

免疫原

Linear peptide corresponding to human GBP5.

应用

Western Blotting Analysis: A representative lot from an independent laboratory detected GBP5 in differentiating THP-1 cells which were untreated or treated with LPS alone, or LPS/IFN-gamma (Shenoy, A. R., et al. (2012). Science. 336(6080):481-485.).
Detect GTP binding protein using this rabbit polyclonal antibody, Anti-GBP5 Antibody validated for use in western blotting.
Research Category
Signaling
Research Sub Category
Immunological Signaling

质量

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 1 ?g/mL of this antibody detected GBP5 in 10 ?g of K562 cell lysate.

目标描述

~67 kDa observed. A second isoform is known to exist at 55 kDa Uncharacterized band(s) may be observed in some cell lysates.

外形

Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) western blot: suitable
NCBI登记号 NP_001127958
UniProt登记号 Q96PP8
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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