Anti-FYVE Antibody, clone 7F11.1

半岛bd体育手机客户端 说明

一般描述

FYVE, also known as Zinc finger FYVE domain-containing protein 26, or FYVE domain-containing centrosomal protein (FYVE-CENT), or Spastizin, and encoded by the gene ZFYVE26/KIAA0321, is a phosphosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis. FYVE is recruited to the midbody during cytokinesis and acts as a regulator of abscission. FYVE also be required for efficient homologous recombination DNA double-strand break repair. FYVE is cytoskeleton associated and localized in the cytoplasm in resting cells but at the centrosome during cell division. FYVE is expressed in all cells and tissues. Defects in FYVE may be associated with Spastic paraplegia 15, a form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

免疫原

GST-tagged recombinant protein corresponding to human FYVE.

应用

Anti-FYVE Antibody, clone 7F11.1 detects level of FYVE & has been published & validated for use in FYVE.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human frontal cortex and thalamus tissues.

质量

Evaluated by Immunohistochemistry in human cerebellum tissue.

Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human cerebellum tissue.

目标描述

~285 kDa calculated. Four isoforms are known to exist at 285 kDa (isoform 1), 283 kDa (isoform 2), 78 kDa (isoform 3), and 89 kDa (isoform 4).

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	7F11.1, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable (paraffin)
同位素/亚型	IgG2aκ
NCBI登记号	NP_056161
UniProt登记号	Q68DK2
运输	wet ice
Gene Information	human ... ZFYVE26(23503)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable