Anti-FUSE-binding protein 1 Antibody

半岛bd体育手机客户端 说明

一般描述

FUSE-binding protein 1, also known as Far upstream element-binding protein 1 FBP, FUSE-binding protein 1, DNA helicase V, hDH V, and encoded by the gene name FUBP1, regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. FUSE may act both as activator and repressor of transcription. There are three known FUSE binding proteins (FBP1, FBP2, and FBP3). All three belong to an ancient family of single-stranded DNA binding proteins. These proteins are required for regulation of the c-myc proto-oncogene and have been shown to bind to an A/T-rich element (far-ustream element) located 1.7 kb upstream of the c-myc P2 promoter. Although their primary sequences are closely related, the FBP, FBP2, and FBP3 genes are located on different chromosomes in both mice and humans. FUSE binding proteins are believed to be multifunctional. Besides regulating the transcription of c-myc (and quite likely other targets), the FBP family has been shown to bind a variety of RNAs in vitro.

免疫原

KLH-conjugated linear peptide corresponding to human FUSE-binding protein 1 near the N-terminal.
Epitope: Near N-terminal

应用

This Anti-FUSE-binding protein 1 | ABE1330 antibody is validated for use in WB, IC for the detection of FUSE-binding protein 1 | ABE1330.
Research Sub Category
Nuclear Receptors
Research Category
Epigenetics & Nuclear Function
Immunocytochemistry Analysis: 2.0 ?g/mL from a representative lot detected FUSE-binding protein 1 in HeLa and A431 cells.

质量

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected FUSE-binding protein 1 in 10 ?g of HeLa cell lysate.

目标描述

~76 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
species reactivity (predicted by homology)	mouse (based on 100% sequence homology), primate (based on 100% sequence homology), rat (based on 100% sequence homology), feline (based on 100% sequence homology), horse (based on 100% sequence homology)
technique(s)	immunocytochemistry: suitable western blot: suitable
NCBI登记号	NP_003893
UniProt登记号	Q96AE4
运输	wet ice
Gene Information	human ... FUBP1(8880)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable