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Anti-Foxp3 Antibody (mouse), PE, clone 3G3

品牌
Sigma-Aldrich
货号
MABF464
规格纯度
clone 3G3, 0.2 mg/mL, from mouse
价格
4848.93 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Foxp3 Antibody (mouse), PE, clone 3G3
Forkhead box protein P3, Scurfin
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The 3G3 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is expressed at constitutively high levels in Treg cells, which are further identified as being CD4+ CD25+. In resting conventional T cells (CD4+ CD25-) Foxp3 expression is restricted, and upon TCR activation is expressed only transiently and in a small proportion of cells. However, the growth factor TGF-beta has been shown to induce expression of Foxp3 in na?ve T cells, driving their development into Foxp3+ Tregs, which are called “induced” or “adaptive” Tregs. These cells are phenotypically similar to so-called “natural” Tregs (CD4+ CD25high Foxp3+) which originate in the thymus and comprise the majority of Treg cells. Tregs are critical for maintaining peripheral tolerance and are implicated in the development of autoimmunity.It is important to review the literature in choosing an antibody for the Foxp3 antigen in flow cytometry, as the potential for high background or non-specific staining may be observed. The 3G3 antibody may be used for intracellular detection of Foxp3 in cells from mouse and Rhesus macaque.
This mouse monoclonal antibody Anti-Foxp3 (mouse), PE & clone 3G3 validated for use in Flow Cytometry for the detection of Foxp3.

质量

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 ?g of this antibody detected Foxp3 in one million C57Bl/6 splenocytes.

外形

Size Exclusion Chromatography

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 PE
抗体形式 purified antibody
antibody product type primary antibodies
克隆 3G3, monoclonal
species reactivity mouse
浓度 0.2 mg/mL
technique(s) flow cytometry: suitable
同位素/亚型 IgG1κ
UniProt登记号 Q99JB6
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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