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位置: 首页> 品牌> Sigma-Aldrich> Anti-FoxP1 Antibody

Anti-FoxP1 Antibody

品牌
Sigma-Aldrich
货号
AB2277
规格纯度
from rabbit, purified by affinity chromatography
价格
6022.61 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-FoxP1 Antibody
fork head-related protein like B, forkhead box P1, glutamine-rich factor 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Forkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif. FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development. It is also known to have an important role in conjunction with NFκβ in the development of B-cells and the differentiation of macrophages. Splice variants give rise to four isoforms of FOXP1. The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4. Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed. The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development.

特异性

This antibody recognizes the C-terminus of FOXP1.

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of human FOXP1.
Epitope: C-terminus

应用

Anti-FOXP1 Antibody detects level of FOXP1 & has been published & validated for use in WB, IC, IH.
Research Sub Category
Transcription Factors

Transcription Factors
Research Category
Neuroscience

Epigenetics & Nuclear Function
Immunohistochemistry Analysis: A 1:300 dilution of AB2277 from a previous lot detected FOXP1 in inflammatory skin disorder and normal human kidney-glomerulus tissue.

Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected FOXP1 in NIH/3T3, RAW264.7, and HeLa cells.

质量

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: 1 ?g/mL of this antibody detected multiple isoforms of FOXP1 in 10 ?g of Jurkat cell lysate.

目标描述

FOXP1 has 4 isoforms observed at 75/73, 64 and 54 kDa

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Jurkat cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human, mouse, rhesus macaque, rat
species reactivity (predicted by homology) bovine (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology)
technique(s) immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI登记号 NP_116071
UniProt登记号 Q9H334
运输 wet ice
Gene Information human ... FOXP1(27086)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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