Anti-FOXL1 Antibody

半岛bd体育手机客户端 说明

一般描述

Forkhead box protein L1 (UniProt Q12952; also known as Forkhead-like 11, Forkhead-related protein FKHL11, Forkhead-related transcription factor 7, FREAC-7) is encoded by the FOXL1 (also known as FKHL11, FREAC7) gene (Gene ID 2300) in human. FOXL1 protein belongs to the forehead box (Fox) family of transcription factors characterized by a common DNA-binding domain (the forkhead box). FOXL1 is involved in regulating the proliferation of gastrointestinal epithelial cells. Loss of Foxl1 leads to distorted architecture of the stomach and small intestine in mice due to a markedly increased epithelial proliferation. Foxl1 knockout is correlated with an enhanced Wnt/β-catenin pathway activation as evidenced by increased β-catenin nuclear localization. FOXL1 expression is down-regulated in the majority of human clear cell renal cell carcinoma (ccRCC), at both mRNA and protein levels. FOXL1 expression inversely correlates with the aggressive phenotype of ccRCC and the survival outcome of patients.

免疫原

KLH-conjugated linear peptide corresponding to human FOXL1.

应用

Research Sub Category
Apoptosis - Additional
This Anti-FOXL1 Antibody is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of FOXL1.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FOXL1 in human breast cancer tissue.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected FOXL1 in 10 ?g of human colon tissue lysate.

目标描述

~36 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
species reactivity (predicted by homology)	feline (based on 100% sequence homology), porcine (based on 100% sequence homology), sheep (based on 100% sequence homology), bovine (based on 100% sequence homology), horse (based on 100% sequence homology)
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
NCBI登记号	NP_005241
UniProt登记号	Q12952
运输	wet ice
Gene Information	human ... FOXL1(2300)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable