Anti-Folliculin (FLCN), Antibody clone 8D9.2

半岛bd体育手机客户端 说明

一般描述

Folliculin (FLCN) is a protein with many possible roles. Folliculin may play a role in the pathogenesis of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). But, Folliculin (FLCN) may be a tumor suppressor, however it is also involved in the generation of colorectal tumorigenesis and renal cell carcinoma, and finally Folliculin (FLCN) might be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutations of Folliculin (FLCN) give rise to Birt-Hogg-Dube syndrome, a rare autosomal dominant genodermatosis characterized by hair follicle hamartomas (fibrofolliculomas), kidney tumors, and spontaneous pneumothorax disorders. Folliculin (FLCN) is widely expressed and localized in both the cytoplasm and nucleus depending upon the conditions in both the fetus and the adult.

免疫原

GST-tagged recombinant protein corresponding to human Folliculin (FLCN).

应用

Research Sub Category
Apoptosis - Additional
This Anti-Folliculin (FLCN), Antibody clone 8D9.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of Folliculin (FLCN).
Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected Folliculin (FLCN) in HeLa cells.
Alexa Fluor^?is a registered trademark of Life Technologies .
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected Folliculin (FLCN) in 10 ?g of HeLa cell lysate.

目标描述

~65 kDa observed.

外形

Purified by Ion-Exchange Chromatography
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

法律信息

ALEXA FLUOR is a registered trademark of Life Technologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	8D9.2, monoclonal
species reactivity	human
technique(s)	immunocytochemistry: suitable western blot: suitable
同位素/亚型	IgMκ
NCBI登记号	NP_653207
UniProt登记号	Q8NFG4
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable