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位置: 首页> 品牌> Sigma-Aldrich> Anti-FMO3 Antibody

Anti-FMO3 Antibody

品牌
Sigma-Aldrich
货号
ABS1036
规格纯度
serum, from rabbit
价格
5520.38 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-FMO3 Antibody
Dimethylaniline monooxygenase [N-oxide-forming] 3, Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Dimethylaniline monooxygenase [N-oxide-forming] 3 (EC 1.14.13.8; EC 1.14.13.148; UniProt P31513; also known as Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase) is encoded by the FMO3 (also known as FMOII, TMAU) gene (Gene ID 2328) in human. Flavin-containing mono-oxygenases (FMOs) constitute a family of microsomal chemical- and drug-metabolizing enzymes, with FMO3 being a major form in adult mouse and human liver. FMO3 is responsible for N-oxidation of a malodorous metabolite, trimethylamine (TMA), to the non-odorous trimethylamine N-oxide (TMAO). FMO3 mutations cause trimethylaminuria (TMAU or Fish odor syndrome), a rare inherited disorder due to decreased metabolism of dietary-derived TMA. More than 300 single nucleotide polymorphisms of the human FMO3 have been reported and over 40 of these polymorphisms have been linked to TMAU. 17β-estradiol-dependent ERα activation is reported to play a fundamental role in the regulation of FMO3 gene transcription.

免疫原

Epitope: Internal (N-terminal half).
Linear peptide corresponding to an internal sequence from the N-terminal half of human FMO3.

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FMO3 in human liver tissue.
Detect FMO3 using this Anti-FMO3 Antibody validated for use in Western Blotting, Immunohistochemistry.
Research Category
Signaling
Research Sub Category
Toxicology & Drug Resistance

质量

Evaluated by Western Blotting in human liver microsomal tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected FMO3 in 10 ?g of human liver microsomal tissue lysate.

目标描述

~55 kDa observed. 59.96 kDa calculated.

外形

Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 serum
antibody product type primary antibodies
克隆 polyclonal
species reactivity human
species reactivity (predicted by homology) chimpanzee (based on 100% sequence homology)
technique(s) immunohistochemistry: suitable
western blot: suitable
NCBI登记号 NP_001002294
UniProt登记号 P31513
运输 dry ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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