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位置: 首页> 品牌> Sigma-Aldrich> Anti-FFAR3/GPR41 Antibody, clone 16F4.1

Anti-FFAR3/GPR41 Antibody, clone 16F4.1

品牌
Sigma-Aldrich
货号
MABN898
规格纯度
clone 16F4.1, from mouse
价格
5352.52 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-FFAR3/GPR41 Antibody, clone 16F4.1
Free fatty acid receptor 3, G-protein coupled receptor 41
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Free fatty acid receptor 3 (UniProt O14843; also known as G-protein coupled receptor 41) is encoded by the FFAR3 (also known as GPR41) gene (Gene ID 2865) in human. Free fatty acids (FFAs) act as both energy sources and signaling molecules via G-protein-coupled receptors (GPCRs) called FFARs (FFA receptors). FFAs are categorized by the length of their carbon chains into short-chain FAs (SCFAs; less than 6 carbons), medium-chain FAs (MCFAs; 6–12 carbons), and long-chain FAs (LCFAs; more than 12 carbons). MCFAs and LCFAs activate FFAR1 and FFAR4, whereas SCFAs activate FFAR3 and FFAR2. FFAR3 is an SCFA receptor that can be activated by propionate (C3), butyrate (C4), and valerate (C5). FFAR3 mediates PYY and GLP-1 secretion from endocrine and sympathetic outflow-dependent heart rate regulation and energy expenditure, while β-Hydroxybutyrate, a ketone body produced in the liver during starvation, decreases sympathetic outflow by antagonizing FFAR3. FFAR3 is shown to couple Gαi/o pathway signaling upon activation by propionate binding in primary murine pancreatic beta cells, resulting in an inhibition of glucose-dependent insulin secretion. FFAR3 is a 7-transmembrane (a.a. 20-40, 48-68, 89-111, 133-153, 179-199, 223-243, 259-279) GPCR, having a short N-terminal extracellular portion (a.a. 1-19) and a long C-terminal cytomplasmic tail (a.a. 280-346).

特异性

Clone 16F4.1 targets an epitope in the C-terminal cytoplasmic domain of human FFAR3/GPR41.

免疫原

KLH-conjugated linear peptide corresponding to a C-terminal cytoplasmic domain sequence of human FFAR3/GPR41.

应用

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected FFAR3/GPR41 in human breast cancer tissue, as well as in normal liver, pancreas, and small intestine tissue sections.
This Anti-FFAR3 Antibody, clone 16F4.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of GPR41.

质量

Evaluated by Western Blotting in human adipose tissue lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected FFAR3/GPR41 in 10 ?g of human adipose tissue lysate.

目标描述

~41 kDa observed. 38.65 kDa calculated.

外形

Protein G purified.
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified antibody
antibody product type primary antibodies
克隆 16F4.1, monoclonal
species reactivity human
technique(s) immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_005295
UniProt登记号 O14843

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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