Anti-FANCM Antibody, clone CV5.1

半岛bd体育手机客户端 说明

一般描述

FANCM, also known as Fanconi anemia group M protein (FACM), or ATP-dependent RNA helicase FANCM, or Fanconi anemia-associated polypeptide of 250 kDa (FAAP250), or Protein Hef ortholog, and encoded by the gene FANCM/KIAA1596,is a critical ATPase needed for proper DNA repair. FANCM is found at DNA replication forks and required for cellular resistance to DNA cross-linking agents and for proper DNA repair. FANCM belongs to a multi-subunit FA (Fanconi anemia) complex. FANCM is localized to the nucleus and expressed in most cells. Defects in FANCM may be associated with Fanconi anemia complementation group M (FANCM) a disorder affecting hematopoietic cells can causing anemia, leukopenia and thrombopenia. Patients also have cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition toward malignancies. Patient’s cells show hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.

免疫原

His-tagged recombinant protein corresponding to human FANCM.

应用

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Apoptosis - Additional
Detect FANCM using this Anti-FANCM Antibody, clone CV5.1 validated for use in ICC.

质量

Evaluated by Immunohistochemistry Analysis in A431, HeLa, and HepG2 cells.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected FANCM in A431, HeLa, and HepG2 cells.

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目标描述

230 kDa calculated

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

法律信息

DyLight is a registered trademark of Pierce Biotechnology, Inc.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	CV5.1, monoclonal
species reactivity	human
浓度	0.5 mg/mL
technique(s)	immunocytochemistry: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_065988
UniProt登记号	Q8IYD8
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable