Anti-FANCJ/BACH1 Antibody, clone 2G7

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一般描述

Bach1 and Bach2 constitute a subfamily of the basic region-leucine zipper family. Bach proteins form heterodimers with small Maf proteins, bind to the Maf recognition element (MARE) and repress target gene expression. Transcription regulator protein BACH2 mediates early B cell differentiation and is specifically expressed in pro and mature B-cells. This protein plays an important role in both the immunoglobulin class switch, oncogene-induced senescence, and somatic hypermutation.

免疫原

Linear peptide corresponding to the C-terminus of human FANCJ/BACH1.
Epitope: C-terminus

应用

This Anti-FANCJ/BACH1 Antibody, clone 2G7 is validated for use in western blotting, ICC & IP for the detection of FANCJ/BACH1.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected FANCJ/BACH1 in MCF-7 cells (Cantor, S. B., et al. (2001). Cell. 105(1):149-160.).

Western Blotting Analysis: A representative lot from an independent laboratory detected FANCJ/BACH1 in transfected FA-J cell lysate (Xie, J., et al. (2010). Oncogene. 29(17):2499-2508.).

Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated FANCJ/BACH1 from MCF-7 cell lysate, prior to detecting the immunoprecipitated sample in Western Blot (Cantor, S. B., et al. (2001). Cell. 105(1):149-160.).

质量

Evaluated by Western Blotting in MCF-7 cell lysate.

Western Blotting Analysis: 1 ?g/mL of this antibody detected FANCJ/BACH1 in 10 ?g of MCF-7 cell lysate.

目标描述

~140 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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