Anti-FAF1 Antibody

半岛bd体育手机客户端 说明

一般描述

Fas-associated protein 1 (FAF1) is a member of the TNF receptor superfamily that plays a critical role in apoptosis during development and immune function. FAF1 has two amino-terminal domains with structural homology to ubiquitin. FAF1 has been observed to be one of the components of the death-inducing signaling complex (DISC) during Fas-mediated apoptosis and can bind to caspase-8 and FADD. Additionally, FAF1 has been shown to suppress the activation of the NF-kappaB transcription factor. FAF1 is also known to interact with the inflammatory signaling PYRIN-containing Apaf-1-like proteins (PYPAFs, also called NALPs) such as PYPAF1, PYPAF2 (NALP2), and PYPAF7, suggesting FAF1 may also be involved in the inflammation pathway. FAF1 is widely expressed with highest expression observed in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon.

特异性

This antibody recognizes the C-terminus of FAF1.

免疫原

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human FAF1.

应用

Research Sub Category
Apoptosis - Additional
Immunohistochemistry Analysis: 2.5 ?g/mL from a representative lot detected FAF1 in rat spleen tissue.
Anti-FAF1 Antibody is a highly specific rabbit polyclonal antibody, that targets Fas-associated protein 1 & has been tested in western blotting & IHC.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 2 ?g/mL of this antibody detected FAF1 in 15 ?g of Jurkat cell lysate.

目标描述

~78 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~57 kDa and ~74 kDa

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Jurkat cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	rat, human
technique(s)	immunohistochemistry: suitable western blot: suitable
UniProt登记号	Q9UNN5
运输	wet ice
Gene Information	human ... FAF1(11124)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable