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位置: 首页> 品牌> Sigma-Aldrich> Anti-Excitatory amino acid transporter 2 Antibody, clone G6

Anti-Excitatory amino acid transporter 2 Antibody, clone G6

品牌
Sigma-Aldrich
货号
MAB2262
规格纯度
clone G6, from mouse
价格
6526.19 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Excitatory amino acid transporter 2 Antibody, clone G6
Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2, excitatory amino acid transporter 2, excitotoxic amino acid transporter 2, glial high affinity glutamate transporter, solute carrier
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The activity of the main glutamate transporter in the CNS, Excitatory amino acid transporter 2 (also known as GLT1), can be regulated by protein kinase C (PKC). It is known that activation of PKC by phorbol esters promotes the clathrin-dependent internalization of the transporter, followed by its lysosomal degradation. However, the molecular mechanisms that link PKC activation and the internalization of the excitatory amino acid transporter 2 are not fully understood. The internalization process may play a role in the ubiquitylation of lysine residues located in the C-terminal tail of the excitatory amino acid transporter 2. Exposure to PMA increases the ubiquitylation of the excitatory amino acid transporter 2 in transfected cells and in the rat brain, and this ubiquitylated excitatory amino acid transporter 2 accumulates in the intracellular compartment. The activation of PKC induces the ubiquitylation of these C-terminal lysine residues in the Excitatory amino acid transporter 2 and this modification mediates the interaction of the transporter with the endocytic machinery.

特异性

This antibody recognizes the C-terminus of Excitatory amino acid transporter 2.

免疫原

Linear peptide corresponding to the C-terminus of human Excitatory amino acid transporter 2.
Epitope: C-terminus

应用

Western Blot Analysis: 0.5 ?g/ml from a previous lot detected Excitatory amino acid transporter 2 on 10 ?g of human brain tissue lysate.
Research Sub Category
Signaling Neuroscience
Research Category
Neuroscience
This Anti-Excitatory amino acid transporter 2 Antibody, clone G6 is validated for use in WB, IH, IC for the detection of Excitatory amino acid transporter 2.

质量

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 0.5 ?g/ml of this antibody detected Excitatory amino acid transporter 2 on 10 ?g of mouse brain tissue lysate.

目标描述

62 kDa

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Mouse brain tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 G6, monoclonal
species reactivity human, mouse
species reactivity (predicted by homology) rat (100% immunogen homology)
technique(s) immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_004162
UniProt登记号 P43004
运输 wet ice
Gene Information human ... SLC1A2(6506)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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