Anti-ERLEC1 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Endoplasmic reticulum lectin 1 (ERLEC1), also called Erlectin (XTP3-B), belongs to mannose 6-phosphate receptor homology (MRH) domain family. It has a signal peptide and two MRH domains. The ERLEC1 gene is mapped to human chromosome 2p16.2.

免疫原

endoplasmic reticulum lectin 1 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

Endoplasmic reticulum lectin 1 (ERLEC1) plays a key role in sorting of misfolded glycoproteins and their endoplasmic reticulum-associated degradation (ERAD). In mammals, ERLEC1 coordinates with amplified in osteosarcoma 9 (OS-9) and monitors protein misfolding and channelizes them for ubiquitin conjugation and degradation. It interacts with endoplasmic reticulum chaperones GRP94 (94-kDa glucose-regulated protein, an ER Hsp90 family member) and BiP (immunoglobulin heavy chain-binding protein, an ER Hsp70 family member) through the MRH domain.

特点和优势

Prestige Antibodies^?are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^?to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST78933.

外形

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

基本信息

人类蛋白质图谱编号

HPA031503 Human Protein Atlas characterization data

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
半岛bd体育手机客户端 线	Prestige Antibodies?Powered by Atlas Antibodies
形式	buffered aqueous glycerol solution
species reactivity	human
增强验证	recombinant expression independent Learn more aboutAntibody Enhanced Validation
technique(s)	immunoblotting: 0.04-0.4 μg/mL immunohistochemistry: 1:50-1:200
免疫原序列	SDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEEEEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKH
UniProt登记号	Q96DZ1
运输	wet ice
储存温度	?20℃
Gene Information	human ... ERLEC1(27248)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable