Anti-EPAC2 Antibody

半岛bd体育手机客户端 说明

一般描述

Exchange factor directly activated by cAMP 2 (EPAC2), also known as Rap guanine nuclear exchange factor 4 (RAPGEF4) and cAMP-regulated guanine nucleotide exchange factor II (cAMPGEF-II), belong to a family of cyclic adenosine monophosphate (cAMP) binding proteins that act as a guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B, and RAP2A small GTPases that are activated through cAMP binding. EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, exocytosis and inflammation. EPAC2 has been found to induce synapse remodeling and depression, with mutations in its gene being found in patients with autism. EPAC2 is predominantly expressed in brain and adrenal gland.

免疫原

KLH-conjugated linear peptide corresponding to human EPAC2.

应用

Anti-EPAC2 Antibody is a highly specific rabbit polyclonal antibody, that targets Epac & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: 2.5 ?g/mL from a representative lot detected EPAC2 in mouse liver tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

质量

Evaluated by Western Blotting/Peptide Inhibition Assay in rat liver tissue lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 ?g/mL of this antibody detected EPAC2 in 15 ?g of rat liver tissue lysate.

目标描述

~129 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 3 isoforms at ~79 kDa, ~100 kDa, and ~116 kDa

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Rat liver tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	rat, mouse
species reactivity (predicted by homology)	human (immunogen homology)
technique(s)	immunohistochemistry: suitable western blot: suitable
UniProt登记号	Q8WZA2
运输	wet ice
Gene Information	human ... RAPGEF4(11069)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable