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Anti-eIF4E antibody produced in rabbit

Anti-eIF4E 兔抗

品牌
Sigma-Aldrich
货号
E5906
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
4187.19 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-eIF4E antibody produced in rabbit
Anti-MGC111573
Anti-eIF4E1
Anti-eIF4EL1
Anti-CBP
Anti-Eukaryotic intiation factor 4E
Anti-EIF4F
Anti-eIF4E 兔抗
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The translational factor eukaryotic translation initiation factor 4E (eIF4E), also known as mRNA cap-binding protein(CBP) or EIF4E1 is a central component of translation initiation and regulation in eukaryotic cells. eIF4E exists as both a free form and as part of a multiprotein complex termed eIF4F. Although mainly expressed in the cytoplasm, a fraction of eIF4E localizes to the nucleus, and some of the biological effects of eIF4E might be effected by a nuclear function.

免疫原

synthetic peptide corresponding to amino acids 21-37 of human eIF4E, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, rat, and mouse.

应用

Anti-eIF4E antibody produced in rabbit has been used in immunoblotting

生化/生理作用

The translational factor eukaryotic translation initiation factor 4EeIF4E regulates the recruitment of mRNAs to the ribosome. Its interaction with mRNA cap structure enhances its binding to eIF4G and 40S ribosomal subunit. eIF4Eplays a role in diverse biological processes including embryonic development, cell cycle progression, synaptic plasticity, and cancer. eIF4E is subjected to tight regulation both at the level of its expression and by control of its activity by phosphorylation mitogen-activated protein kinase (MAPK) interacting protein kinases (by the Mnk kinase). Human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T; eIF4ENIF1), suggesting novel roles for these proteins in targeting mRNAs for 5′ to 3′ degradation.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01633313
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 25 kDa
species reactivity human, mouse, rat (predicted)
浓度 ~1 mg/mL
technique(s) immunocytochemistry: 5-10 μg/mL using paraformaldehyde-fixed 3T3 cells
immunoprecipitation (IP): 2-5 μL using HeLa cell lysates
western blot: 0.5-1 μg/mL using HeLa cell lysates
UniProt登记号 P06730
运输 dry ice
储存温度 ?20℃
Gene Information human ... EIF4E(1977)
mouse ... Eif4e(13684)
rat ... Eif4e(117045)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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