半岛bd体育手机客户端 说明
一般描述
EGLN2 (PHD1) is a prolyl hydroxylase that regulates the degradation of alpha subunit of HIF-1. Furthermore, PHD1 expression is modulated by ARNT during hypoxic conditions. Studies in mice have revealed that EGLN2 can block cancer growth.
Rabbit Anti-EGLN2 antibody recognizes canine, human, mouse, and rat EGLN2.
免疫原
Synthetic peptide directed towards the N terminal region of human EGLN2
应用
Rabbit Anti-EGLN2 antibody can be used for western blot applications at a concentration of 0.5 μg/ml.
生化/生理作用
The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. EGLN2 encodes an enzyme responsible for this posttranslational modification. Alternative splicing of EGLN2 results in three transcript variants encoding different isoforms.
序列
Synthetic peptide located within the following region: SAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRL
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 44 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_444274 |
| UniProt登记号 | Q96KS0 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... EGLN2(112398) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
