半岛bd体育手机客户端 说明
一般描述
EFNB2 (ephrin B2) is a membrane-bound molecule , that is located on human chromosome 13q33.
免疫原
Peptide sequence around aa. 328-332 (N-I-Y-Y-K), according to the protein EFNB2.
生化/生理作用
EFNB2 (ephrin B2) regulates the development of arterial endothelial cell. It also modulates the movement and adherence of vascular smooth muscle cells and pericytes to the extending arterial endothelial cell tubes. Overexpression of EFNB2 results in low tumor stage and elevated expression of TrkA in neuroblastomas. It controls the growth of thymocyte and differentiation of peripheral T cell. It is required for interleukin-6 (IL-6) signaling. It also modulates the antiviral immune responses.
特点和优势
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目标描述
Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~37 kDa |
| species reactivity | rat, human, mouse |
| 浓度 | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (N-I-Y-Y-K) |
| NCBI登记号 | NP_004084.1 |
| UniProt登记号 | P52799 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... EFNB2(1948) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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