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Anti-EB3 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200606
规格纯度
~1.0 mg/mL, affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-EB3 antibody produced in rabbit
Anti-EBF3-S
Anti-member 3
Anti-MAPRE3
Anti-RP3
Anti-RP/EB family
Anti-microtubule-associated protein
Anti-EBF3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

End-binding protein-3 (EB3), also known as microtubule-associated protein RP/EB 3 (MAPRE3), belongs to a distinct family of “plus-end tracking proteins” (+TIPs). EB proteins are among the most conserved components of the microtubules cytoskeleton. EB proteins contain an N-terminal calponin homology (CH) domain and a unique EB-like C-terminal motif. EB3 is exclusively expressed in the central nervous system and it interacts with a CNS-specific APC homolog APCL.

免疫原

Synthetic peptide corresponding to an internal sequence of human EB3, conjugated to KLH. The corresponding sequence is highly conserved (single amino acid substitution) in rat and mouse EB3.

应用

Anti-EB3 antibody produced in rabbit has been used in:

  • immunoblotting
  • co-immunoprecipitation
  • immunocytochemistry
  • glutathione S-transferase (GST) pull-down assay

生化/生理作用

In neurons, End-binding protein-3 (EB3) has been shown to interact with scaffold protein ankyrin-G and PSD95 and is required for stabilizing neuronal polarity in mature neurons and in determining neuronal dendritic morphology. EB3 is also involved in MT polymerization and cell migration. EB3 may be involved in stabilizing MTs and anchoring them to centrosomes during spindle formation. Knockout of EB3 inhibits myoblasts elongation and fusion into myotubes.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~32 kDa
species reactivity rat, human, mouse
浓度 ~1.0 mg/mL
technique(s) immunoblotting: 1-2 μg/mL using lysates of rat brain (S1 fraction)
immunoprecipitation (IP): 5-10 μg using lysates of mouse brain (S1 fraction).
UniProt登记号 Q9UPY8
运输 dry ice
储存温度 ?20℃
Gene Information human ... MAPRE3(22924)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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