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位置: 首页> 品牌> Sigma-Aldrich> Anti-DUOX1 antibody produced in goat

Anti-DUOX1 antibody produced in goat

品牌
Sigma-Aldrich
货号
SAB2501600
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
4618.16 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-DUOX1 antibody produced in goat
Anti-MGC138841
Anti-LNOX1
Anti-DUOX1
Anti-MGC138840
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The gene DUOX1 (dual oxidase 1) encodes a protein belonging to the family of NADPH oxidase/heme peroxidase proteins, Duox, and shares upto 85% amino acid similarity with another Duox isoform, Duox2. It contains an NAD(P)H oxidase domain and a heme peroxidase domain. The NAD(P)H oxidase domain of this protein is involved in H2O2production and the heme peroxidase domain is similar to several peroxidases, but its function is yet to be characterized. The expression of Duox1 is stimulated by Th2 (T helper) cytokines, IL-4 (interleukin-4) and IL-13 (interleukin-13). The gene is mapped to human chromosome 15q15.3.

免疫原

Peptide with sequence EKFQRSCLHQTVQ, from the internal region of the protein sequence according to NP_059130.2 ; NP_787954.1

生化/生理作用

The gene DUOX1 (dual oxidase 1) encodes a dual function NAD(P)H oxidase/peroxidase that serves as an important source for the production of hydrogen peroxide in respiratory tract epithelium. H2O2, thus produced, is involved in the regulation of cellular signaling pathways that participate in the production of inflammatory effectors. ATP-mediated activation of duox1 causes activation of ERK1/2 (extracellular signal-regulated kinase ?) and NFκ-B (nuclear factor κ-light-chain-enhancer of activated B cells) pathways. Duox1 is also involved in the regulation of pathways associated with production of various mucins, matrix metalloproteinase-9, and other inflammatory mediators, in response to environmental or bacterial stimuli.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 goat
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human
technique(s) immunohistochemistry: suitable
indirect ELISA: suitable
UniProt登记号 Q9NRD9
运输 dry ice
储存温度 ?20℃
Gene Information human ... DUOX1(53905)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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