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位置: 首页> 品牌> Sigma-Aldrich> Anti-Dual oxidase 2, clone Duox S-12 Antibody

Anti-Dual oxidase 2, clone Duox S-12 Antibody

品牌
Sigma-Aldrich
货号
MABN787
规格纯度
clone Duox S-12, from mouse
价格
5520.38 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-Dual oxidase 2, clone Duox S-12 Antibody
Dual oxidase 2, Large NOX 2, Long NOX 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, Thyroid oxidase 2, p138 thyroid oxidase
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Dual oxidase 2 is an important enzyme in thyroid hormone biosynthesis and peroxide metabolism. Dual oxidase 2 generates the hydrogen peroxide needed for thyroid peroxidase and lactoperoxidase enzymes as well as processes H2O2 made during metabolic processes. Dual oxidase also plays a role in anti-microbial defense in our mucous membranes by providing the peroxidase for lactoperoxidase’s antimicrobial activities. Dual oxidase 2 is also needed for various extracellular matrix stabilizations and protein cross-linking needs such as during cuticle formation. Dual oxidase 2 is widely expressed in the developing fetus, and in the adult, it is largely expressed in the mucosal and epithelial cells and linings of the gut, lung, salivary glands and testis. Dual oxidase also plays a role in many hypersensitivity and inflammatory diseases and is upregulated in diseases such as colitis and certain cancers.

免疫原

Epitope: N-terminus
Recombinant protein corresponding to the N-terminus of human Dual oxidase 2.

应用

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Dual oxidase 2 in human prostate cancer and human breast cancer tissue.
Western Blotting Analysis: A representative lot detected Dual oxidase 2 in BxPC-3 cell lysate (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).
Immunocytochemistry Analysis: A representative lot detected Dual oxidase 2 in MIA PACA-2 cell (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).
Immunohistochemistry Analysis: A representative lot detected Dual oxidase 2 MIA PACA-2 tissue (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).
This Anti-Dual oxidase 2, clone Duox S-12 Antibody is validated for use in Western Blotting and Immunohistochemistry and Immunocytochemistry for the detection of Dual oxidase 2.

质量

Evaluated by Western Blotting in BxPC3 treated with IL-4 cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected Dual oxidase 2 in 10 ?g of BxPC3 treated with IL-4 cell lysate.

目标描述

~175 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 Duox S-12, monoclonal
species reactivity human
technique(s) immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_054799
UniProt登记号 Q9NRD8
运输 wet ice
Gene Information human ... DUOX2(50506)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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