Anti-DR4 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1), also known as DR4, is encoded by the gene mapped to human chromosome 8p21-22. It belongs to the TNFR superfamily of transmembrane proteins. TRAIL-R1 contains a cytoplasmic "death domain," which can activate the cell′s apoptotic machinery. TRAIL receptor-1/DR4 is activated by binding to either membrane anchored or soluble TRAIL/Apo2L.

免疫原

DR4 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR4 protein.

应用

Anti-DR4 antibody produced in rabbit has been used in western blotting.

生化/生理作用

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) interacts with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and stimulates cell-death signaling pathway. Mutation of the sTRAIL-R1 gene is associated with the pathogenesis of non-Hodgkin′s lymphoma (NHL). In addition, variation of TRAIL-R1 also increases the risk of susceptibility to prostate cancer (PCa) in North Indian population.

特点和优势

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联系

The action of this antibody can be blocked using blocking peptide SBP3500428.

外形

Supplied in PBS with 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD01864349
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	IgG fraction of antiserum
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	predicted mol wt 56 kDa
species reactivity	human
technique(s)	immunocytochemistry: suitable immunofluorescence: suitable immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable
NCBI登记号	AAC51226
UniProt登记号	O00220
运输	dry ice
储存温度	?20℃
Gene Information	human ... TNFRSF10A(8797)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable