Anti-DISC1 Antibody, clone 3D4

半岛bd体育手机客户端 说明

一般描述

Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.

免疫原

Recombinant protein corresponding to human DISC1.

应用

This Anti-DISC1 Antibody, clone 3D4 is validated for use in IHC (Paraffin), western blotting andICC for the detection of DISC1.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DISC1 in human cerebellum and human cerebral cortex tissue.
Western Blotting Analysis: A representative lot detected DISC1 in human NLF cell lysate (Leliveld, S. R., et al. (2008). Journal of Neuroscience. 28(15):3839-3845).
Immunocytochemistry Analysis: A representative lot detected DISC1 in transfected cells (Bader, V., et al. (2012). Human Molecular Genetics. 21(20):4406-4418).
Immunohistochemistry Analysis: A representative lot detected DISC1 in human cortical tissue sections (Seshadri, S. et al. (2010). PNAS. 107(12):5622-5627).
Immunohistochemistry Analysis: A representative lot detected DISC1 in human brain tissue (Bader, V., et al. (2012). Human Molecular Genetics. 21(20):4406-4418).
Research Category
Neuroscience
Research Sub Category
Developmental Signaling

质量

Evaluated by Immunohistochemistry in human cerebral cortex tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected DISC1 in human cerebral cortex tissue.

目标描述

94 kDa calculated

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	3D4, monoclonal
species reactivity	human
浓度	1 mg/mL
technique(s)	immunocytochemistry: suitable immunohistochemistry: suitable (paraffin) western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_001012975
UniProt登记号	Q9NRI5
运输	wet ice
Gene Information	human ... DISC1(27185)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable