Anti-DISC1 Antibody

半岛bd体育手机客户端 说明

一般描述

Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.

免疫原

KLH-conjugated linear peptide corresponding to human DISC1.

应用

Anti-DISC1 detects levels of DISC1 proteins & has been published & validated for use in IHC, ICC & WB.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody lot detected DISC1 in rat cerebellum tissue.

Immunocytochemistry Analysis: A 1:2,000 dilution from a representative lot detected DISC1 in HeLa cells.

Western Blot Analysis: 2 ?g/mL from a representative lot detected DISC1 in 10 ?g/mL of SK-N-SH cell lysate and mouse brain tissue lysate.

质量

Evaluated by Immunohistochemistry in human brain tissue.

Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody lot detected DISC1 in human brain tissue.

目标描述

~94 kDa observed. Uniprot describes 8 isoforms ranging between ~39 kDa and ~94 kDa; however, there are many additional isoforms of DISC1 known to exist. (Ishizuka, K., et al. (2007). Molecular Psychiatry. 12:897-899.)

外形

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human brain tissue

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human, mouse, rat
technique(s)	immunocytochemistry: suitable immunohistochemistry: suitable western blot: suitable
UniProt登记号	Q9NRI5
运输	wet ice
Gene Information	human ... DISC1(27185)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable