ANTI-DIO3 (C-TERM) antibody produced in rabbit

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一般描述

Iodothyronine deiodinase 3 (DIO3) is highly expressed in central nervous system, fetal liver and placenta. DIO3 is a selenoenzyme with insertion sequence element containing selenocysteine in the 3′UTR (untranslated region). In human chromosome, the gene DIO3 is localized on 14q32.31.

生化/生理作用

Iodothyronine deiodinase 3 (DIO3) regulates the serum level of thyroid hormone. DIO3 removes iodine from the inner ring of T4 (thyroxine) and T3 (triiodothyronine) and converts to its inactive forms. The major role of DIO3 is to protect exposure of fetal tissues to high level of T3 throughout gestation. Elevated expression of DIO3 is associated with infantile hepatic hemangiomas (IHH). Alterations in the thyroid hormone exposure during developmental stages may cause phenotypes similar to uniparental disomy of chromosome 14. The lack of DIO3 leads to neonatal thyrotoxicosis, followed by hypothyroidism. DIO3 is crucial for auditory development. Mutations in DIO3 leads to deafness due to immature cochlear differentiation. DIO3 protects the immature cones by regulating the hormonal exposure, facilitating cone survival and opsins patterning.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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