Anti-DENR Antibody, clone 10D9.1

半岛bd体育手机客户端 说明

一般描述

The protein named density-regulated protein (DRP1), also known as DRP, or Protein DRP1 or Smooth muscle cell-associated protein 3 (SMAP-3), and encoded by the gene DENR/DRP1, is an important translational control protein that appears to function by scanning target mRNAs for the recognition codon when complexed with the translational initiation complex. DRP1 also modulates the translation of particular cancer-related mRNAs when recruited to the translational complex by the oncogene MCTS1 and DRP1 is up regulated in many cancers such as ovarian and breast cancers. Additionally, DRP1’s expression is regulated by increasing cell density through interaction with heterogeneous nuclear ribonucleoprotein D (HNRNPD) protein, a critical protein that complexes with heterogeneous nuclear RNA and pre-mRNAs and fosters mRNA stability. Density-regulated protein (DRP1) is localized to the in heart, skeletal muscle, brain, placenta, liver and pancreas, with weaker expression seen in lung and kidney.

免疫原

GST-tagged recombinant protein corresponding to the C-terminus of human DENR.

应用

Anti-DENR Antibody, clone 10D9.1 is a mouse monoclonal antibody, validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DENR in human cerebral cortex and human cardiac myocytes tissue.

质量

Evaluated by Western Blotting in PC-12 cell lysate.

Western Blotting Analysis: 2.0 ?g/mL of this antibody detected DENR in 10 ?g of PC-12 cell lysate.

目标描述

~22 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	10D9.1, monoclonal
species reactivity	rat, human
technique(s)	immunohistochemistry: suitable western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_003668
UniProt登记号	O43583
运输	wet ice
Gene Information	human ... DENR(8562)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable