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位置: 首页> 品牌> Sigma-Aldrich> Anti-DARPP-32 antibody produced in rabbit

Anti-DARPP-32 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4503329
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-DARPP-32 antibody produced in rabbit
Dopamine- and cAMP-regulated neuronal phosphoprotein
Neuronal phosphoprotein DARPP-32
PPP1R1B
IPPD
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Anti-DARPP-32 Antibody detects endogenous levels of total DARPP-32 protein.
PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B)/DARPP32 (dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa) encodes two transcripts which are further translated into two DARPP-32 protein isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. It is located on human chromosome 17q12.
The DARPP-32 (dopamine and cAMP-regulated neuronal phosphoprotein 2) gene is mapped to human chromosome 17q12. The gene is expressed predominantly in spiny neurons of the neostriatum and specifically localized in caudate, putamen, nucleus accumbens, cerebral and cerebellar cortex. The gene encodes two isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. The lack of the first 36 residues at the N-terminal in t- DARPP marks the difference between the two isoforms. Anti-DARPP-32 Antibody detects endogenous levels of total DARPP-32 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human DARPP-32.

Immunogen Range:41-90

生化/生理作用

DARPP-32 (dopamine and cAMP-regulated neuronal phosphoprotein 2) is a dopaminergic gene that influences dopamine receptor binding potential in the corpus striatum. The gene also regulates the availability of dopamine neurotransmitter, which is important for cognitive capacities. Therefore, variation in this gene affects category learning performance. (t)-DARPP takes part in the process of tumorigenesis by stimulating chemokine receptor 4 and also promoting cell proliferation. Elevated expression of the DARPP-32 gene in dorsolateral prefrontal neocortex and hippocampus is correlated with the development of schizophrenia and cognitive disorders. The encoded protein is a phosphorylation-dependent inhibitor. DARPP-32 is associated with the pathogenesis of gastric cancer and breast cancer with its anti-apoptotic property, and is found to promote angiogenesis.
PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B)/DARPP32 (dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa) is considered as an inhibitor of phosphate-1 (PP-1) protein. It is associated with working memory and emotion processing.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD03454936
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 22 kDa
species reactivity rat, mouse, human
浓度 ~1 mg/mL
technique(s) ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号 Q9UD71
UniProt登记号 Q9UD71
运输 wet ice
储存温度 ?20℃
Gene Information human ... PPP1R1B(84152)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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