半岛bd体育手机客户端 说明
一般描述
Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.
免疫原
Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4
生化/生理作用
Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.
特点和优势
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外形
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
基本信息
NACRES | NA.41 |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous glycerol solution |
species reactivity | rat, human, mouse |
technique(s) | immunohistochemistry: 1:20-1:100 western blot: 1:500-1:2000 |
登记号 | NP_001888 |
UniProt登记号 | Q6UVK1 |
运输 | wet ice |
储存温度 | ?20℃ |
Gene Information | human ... CSPG4(1464) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich