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Anti-CRYAB antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701705
包装型号
规格纯度
价格
4668.88 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-CRYAB antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

免疫原

A synthesized peptide derived from human CRYAB

外形

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
antibody product type primary antibodies
克隆 monoclonal
形式 liquid
species reactivity mouse, rat, human
浓度 0.25 mg/mL
technique(s) immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000
UniProt登记号 P02511
运输 wet ice
储存温度 ?20℃
Gene Information human ... CRYAB(1410)

安全信息

闪点(F) Not applicable
闪点(C) Not applicable

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