Anti-CPT2 Antibody

半岛bd体育手机客户端 说明

一般描述

Carnitine palmitoyltransferase II (CPT2, or CPT II) belongs to the carnitine/choline acetyltransferase family. It is a ubiquitous protein found in the inner membrane of the mitochondria and plays an essential role in fatty acid β-oxidation. CPT2 is part of the system involving CPT1 and carnitine/acylcarnitine translocase (CACT), that facilitate the transport of long chain fatty acids into the mitochondrial matrix. CPT2 plays the role of restoring these molecules to original esterified forms suitable for β-oxidation, after they arrive in the matrix. Defects in CPT2 has varying outcomes: in adults, it results in episodes of rhabdomyolysis (breakdown of muscle fibers which circulate in the bloodstream), after prolonged and vigorous exercise; and in infants, CPT2 deficiency induces hypoketotic hypoglycemia and eventual cardiac damage.

免疫原

KLH-conjugated linear peptide corresponding to human CPT2.

应用

Anti-CPT2 detects levels of CPT2 proteins & has been published & validated for use in WB.

质量

Evaluated by Western Blot in rat liver mitochondria tissue lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected CPT2 on 10 ?g of rat liver mitochondria tissue lysate.

目标描述

~68 kDa observed (cleaved form). Uniprot gives a calculated weight of 74 kDa; however, CPT2 has been observed at ~68 kDa (Faye, A, et al. (2007). The Journal of Biological Chemistry. 282(37):26908–26916.). Uncharacterized bands appear at ~55, 58, 72, and 100 kDa in some lysates.

外形

Unpurified

分析说明

Control
Rat liver mitochondria tissue lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	serum
antibody product type	primary antibodies
克隆	polyclonal
species reactivity	rat
species reactivity (predicted by homology)	human (immunogen homology)
technique(s)	western blot: suitable
同位素/亚型	IgG
NCBI登记号	NP_000089
UniProt登记号	P23786
运输	wet ice

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1