Anti-COG6 (C-terminal) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Conserved Oligomeric Golgi complex 6 (COG6), also known as COD2, is a member of the conserved oligomeric Golgi (COG) complex. COG complex is composed of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3- Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.

免疫原

a peptide corresponding to the C-terminal region of human COG6, conjugated to KLH. The corresponding sequence differs by three amino acids in mouse and rat COG6.

应用

Anti-COG6 (C-terminal) antibody produced in rabbit has been used in various immunochemical techniques including immunoblotting and immunoprecipitation.

生化/生理作用

COG complex is an evolutionarily conserved multi-subunit protein complex that regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. COG complex interacts directly with the target membrane (t-SNARE) Syntaxin 6 through COG6 subunit. COG6-depleted cells display reduced steady-state level of Syntaxin 6 and attenuated endosome-to- trans‐Golgi network (TGN) retrograde trafficking. Deficiency of COG6 causes a combined N- and Oglycosylation deficiency of the congenital disorders of glycosylation, designated as CDG-IIL (COG6- congenital disorders of glycosylation (CDG)).

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen ~70 kDa
species reactivity	human
浓度	~1.0 mg/mL
technique(s)	immunoprecipitation (IP): 5-10 μg using lysates of human HeLa cells western blot: 2-4 μg/mL using whole extracts of human HEK-293T cells
UniProt登记号	Q9Y2V7
运输	dry ice
储存温度	?20℃
Gene Information	human ... COG6(57511)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable